|
Name of treatment |
Amitriptyline |
|
Type of treatment |
Pharmaceutical |
|
Claims for treatment |
Reduces/eliminates the tinnitus percept. |
|
How treatment is delivered |
Oral administration |
|
Potential negative consequences |
Common side effects from clinical trials included: sedation, sexual dysfunction and dry mouth1. |
Evidence offered: |
|
|
Papers available |
2 (as in the Cochrane review[1]) |
|
Conclusions drawn |
It is yet unclear if the potential benefits of antidepressants stem from reducing tinnitus distress or depression; well designed, long studies are necessary. The studies reviewed were not of good enough quality nor long enough duration to be reliable. |
|
Quality of evidence[2] |
A |
|
Does the BTA recommend this treatment? |
Yes, where clinically indicated for low mood |
|
BTA opinion on this treatment: |
Antidepressants may be administered to diminish depression and anxiety in tinnitus. There are, however, low evidence levels for the administration of antidepressants for reducing tinnitus distress. We suggest talking to your doctor about the potential effects and side effects of antidepressants. |
|
Would the BTA support further studies into this treatment? |
Yes, if a high-quality study |
|
Verdict: Safety – is this treatment harmful? |
|
|
Verdict: Efficacy – does this treatment work? |
|
Limited potential for harm[1] Baldo P, Doree C, Molin P, McFerran D, Cecco S. Antidepressants for patients with tinnitus. Cochrane Database of Systematic Reviews 2012, Issue 9. Art. No.: CD003853. DOI: 10.1002/14651858.CD003853.pub3.
[2] A = Systematic review/meta analysis. B = Randomised control studies. C = Cohort studies. D = Case control studies. E = case studies/reports. +/- to be used to indicate quality within bands
Download this information:
Tinnitus_and_amitriptyline_June_2019.pdf
Updated 11 June 2019
Photo: courtesy Rünno [Public domain]
