Tinnitus and Synapse XT | British Tinnitus Association

Name of treatment

Synapse XT

Does the BTA recommend this treatment?


BTA opinion on this treatment:

Although independent evidence is limited, what there is does not show that the components of this supplement are effective for tinnitus. We would suggest you talk to your GP before taking any new medication or supplement.

“Dietary supplements should not be recommended to treat tinnitus.”[23]

Type of treatment

Dietary supplement

Claims for treatment

“support your hearing, memory and focus.”

“support the communication between your cells to minimize signs of brain fatigue.”[1]

How treatment is delivered

Orally. The supplement is a combination of:


Hawthorn berry

B vitamins

Vitamin C


Juniper berry

Green tea[2]

However, an image of the bottle label lists the ingredients as:


Vitamin B6


Magnesium citrate

Potassium citrate



Hawthorn berry


There are claims that “Synapse XT supplement is extraordinarily formulated with around 233 unique and effective ingredients that have a lot of other health benefits in improving the overall functioning of our body.”[4]

We have been unable to find out what they are.

However, there appears to be a lot of similarity between this product and Sonus Complete – please see the relevant information sheet for details.

Potential negative consequences

Side effects[5] [6]

Cost – this supplement currently is on sale for $69 for one month’s supply excluding shipping and taxes.

Evidence offered:


Papers available

There have been no papers published on Synapse XT as a supplement, but there have been a number published on its component parts.

Conclusions drawn

Studies suggest hibiscus has antibacterial, anti-oxidant, diuretic and anti-hypertensive effects. It is regarded as safe [7].

Hawthorn extracts have been used in the treatment of heart problems, including heart failure as it increases coronary blood flow. It can lower blood pressure.[8] Although it may interact with some medications, it is regarded as safe.[9]

Vitamin C is important for bones, connective tissue, muscles, blood vessels. It helps the body absorb iron, needed for red blood cell production. Side effects are rare.[10]

Vitamin B6 is used to treat a type of anaemia (lack of red blood cells). High levels of supplementation or prolonged use can cause severe nerve damage.[11] This supplement contains the recommended upper limit.[12]

Folic acid (folate) is needed to make DNA and other genetic material. Side effects are rare.[13]

It is not certain whether garlic is effective in treating any medical condition. It is safe as a foodstuff but unregulated as a supplement.

It has been suggested that juniper berries have potential antimicrobial, antioxidant and neuroprotective effects but no clinical data exists to support the use of juniper for any indication. It should not be used by someone who is pregnant/breastfeeding.[14]

Green tea has been used as an aid in treating high cholesterol and maintaining mental alertness[15] but it uncertain whether it is effective in treating any medical condition. Green tea supplements can be toxic in large doses.[16]

Serum magnesium levels are lower in people with tinnitus than in the general population[17]. A small open label study showed positive results.[18]

Potassium is most commonly used for treating high blood pressure. It has a role in the transmission of nerve signals[19]. Too much potassium is unsafe.[20]

Rosemary is claimed to be beneficial for improving memory, joint pain and hair loss, but there is no good scientific evidence to support claims for its use medically.[21]

Quality of evidence[22]

A – D

Would the BTA support further studies into this treatment?


Verdict: Safety – is this treatment harmful?

 No evidence of harm if product declaration is accurate

Verdict: Efficacy – does this treatment work?

  No evidence of effect

Date completed

October 2020

Date for revision

October 2023


We welcome feedback on all our information. Please send any corrections or updates for consideration to Nic Wray, Communications Manager on [email protected]

Download this information:


[1] www.synapsext.com [accessed 1 October 2020]

[2] www.synapsext.com [accessed 1 October 2020]

[3] https://synapsext.com/pages/references/ [accessed 1 October 2020]

[4] https://www.phdsc.org/synapse-xt-review [accessed 1 October 2020]

[5] https://www.drugs.com/niacin.html [accessed 11 August 2020]

[6] National Institutes of Health Office of Dietary Supplements. Vitamin B6 https://ods.od.nih.gov/factsheets/VitaminB6-Consumer/ [accessed 11 August 2020]

[7] Da Costa Rocha I, Bonnlaender B, Sievers H, Pischel I, Heinrich M (2014) Hibiscus Sabdariffa L. – A Phytochemical and Pharmacological Review. Food Chemistry. 165, 424-43. DOI: 10.1016/j.foodchem.2014.05.002

[8] Orhan IE. (2018) Phytochemical and Pharmacological Activity Profile of Crataegus Oxyacantha L. (Hawthorn) – A Cardiotonic Herb. Current Medicinal Chemistry. 25(37) 4854-4865. DOI: 10.2174/0929867323666160919095519

[9] ibid

[10] https://www.drugs.com/mtm/vitamin-c.html [accessed 11 August 2020]

[11]National Institutes of Health Office of Dietary Supplements. Vitamin B6 https://ods.od.nih.gov/factsheets/VitaminB6-Consumer/ [accessed 11 August 2020]

[12] https://synapsext.com/pages/references/  [accessed 11 August 2020]

[13] https://www.drugs.com/folic_acid.html [accessed 11 August 2020]

[14] https://www.drugs.com/npp/juniper.html [accessed 11 August 2020]

[15] https://www.drugs.com/mtm/green-tea.html [accessed 11 August 2020]

[16] Hu J, Webster D, Cao J, Shao A. (2018). The Safety of Green Tea and Green Tea Extract Consumption in Adults – Results of a Systematic Review. Regulatory Toxicology and Pharmacology. 95. 412-433. DOI: 10.1016/j.yrtph.2018.03.019

[17] Uluyol S, Kılıçaslan S, Yağız Ö. Relationship between serum magnesium levels and subjective tinnitus. Kulak Burun Bogaz Ihtis Derg, 2016: 26(4), 225-7

[18] Patel, A. Phase Two Study Examining Magnesium Dependent Tinnitus, 2012. Thesis, The University of Arizona. http://hdl.handle.net/10150/221385 (accessed 17 July 2017)

[19] https://www.webmd.com/vitamins/ai/ingredientmono-851/potassium [accessed 1 October 2020]

[20] https://www.webmd.com/vitamins/ai/ingredientmono-851/potassium [accessed 1 October 2020]

[21] https://www.webmd.com/vitamins/ai/ingredientmono-154/rosemary [accessed 1 October 2020]

[22] A = Systematic review/meta analysis. B = Randomised control studies. C = Cohort studies. D = Case control studies. E = case studies/reports. +/- to be used to indicate quality within bands

[23] Coelho C, Tyler R, Ji H, Rojas-Roncancio E, Witt S, Tao P, Jun HJ, Wang TC, Hansen MR, Gantz BJ. (2016) Survey on the Effectiveness of Dietary Supplements to Treat Tinnitus. American Journal of Audiology. 25(3): 184-205

Updated 2 October 2020

Image by GOKALP ISCAN from Pixabay

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